姓名：任凯群
照片：
职称：副教授
职务：医学院实验中心副主任
专业：免疫学
联系电话：0731-88912434（Office）；15116261816 (Cell phone)
电子邮箱：kaiqunren@hunnu.edu.cn
通讯地址：湖南省长沙市岳麓区桐梓坡路371号，mk体育（MKsports集团）股份公司,仁医楼A栋406室，邮编：410013
简介：
任凯群，副教授，硕士生导师，南京大学博士，2016-2017年美国明尼苏达大学访问学者。研究方向为疾病动物模型构建和利用，擅长动物模型在体研究。 主持国家自然科学基金项目1项，湖南省自然科学基金项目2项，教育厅重点项目1项。
主持科研项目：
1，KCTD10通过Notch信号通路调控肝干细胞形成与分化的分子机制研究，国家自然科学基金，2016-2018（项目编号31501913）
2，KCTD10的表达调控对LCSCs自我更新能力以及药物增敏性研究，湖南省自然科学基金委，2016-2018（项目编号2015JJ6072）
3，湖南省自然科学基金，2020JJ4441，KCTD10对2型免疫反应（Th2）的调控研究，2020-2022
4，教育厅重点，20A304，KCTD10的缺失对肠道表型及功能分析，2021-2023
5，横向课题，人脐带间充质干细胞和自然杀伤细胞外泌体抗皮肤糖化衰老及损伤修复研究，2024-2025
代表性学术论文
1.Wu J, Yang Z, Wang D, Xiao Y, Shao J,Ren K. Human Umbilical Cord Mesenchymal Stem Cell-derived Exosome Regulates Intestinal Type 2 Immunity. Curr Stem Cell Res Ther. 2024 May 22. doi: 10.2174/011574888X314032240429113240. Epub ahead of print. PMID: 38779734. (通讯作者)
2. Ma T, Wang D, Wu J, Xiao Y, Fan A, Cao X, Cao J,Ren K#. KCTD10 functions as a tumor suppressor in hepatocellular carcinoma by triggering the Notch signaling pathway.Am J Transl Res.2023 Jan 15;15(1):125-137. PMID: 36777839; PMCID: PMC9908486. (通讯作者)
3. Zhao M,Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z#, Ruan HB#. Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.Immunity.2022 Apr 12;55 (4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5. PMID: 35385697.
4. Wang XL, Cao XZ, Wang DY, Qiu YB, Deng KY, Cao JG, Lin SQ, Xu Y,Ren K#. Casticin Attenuates Stemness in Cervical Cancer Stem-Like Cells by Regulating Activity and Expression of DNMT1.Chin J Integr Med.2023 Mar;29(3):224-232. doi: 10.1007/s11655-022-3469-z. Epub 2022 Jul 9. PMID: 35809177. (通讯作者)
5. Zhao M,Ren K, Xiong X, Cheng M, Zhang Z, Huang Z, Han X, Yang X, Alejandro EU, Ruan HB#. Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells.Cell Rep.2020 Aug 11;32(6):108013. doi: 10.1016/j.celrep.2020.108013. PMID: 32783937; PMCID: PMC7457433.
6. Cao X, Liu L, Cao X, Cui Y, Zou C, Chen A, Qiu Y, Quan M,Ren K#, Chen X#, Cao J#. The DNMT1/miR-34a/FOXM1 Axis Contributes to Stemness of Liver Cancer Cells.J Oncol.2020 Apr 5;2020:8978930. doi: 10.1155/2020/8978930. PMID: 32308683; PMCID: PMC7142390.（通讯作者）
7. X. Cao, L. Liu, Q. Yuan, X. Li, Y. Cui,Ren, K., C. Zou, A. Chen, C. Xu, Y. Qiu, M. Quan, J. Zhang, J. Cao, X. Chen#, Isovitexin reduces carcinogenicity and stemness in hepatic carcinoma stem-like cells by modulating MnSOD and FoxM1.Journal of Experimental & Clinical Cancer Research: CR 38 (2019) 264.（通讯作者）
8. Xu C, Cao X, Cao X, Liu L, Qiu Y, Li X, Zhou L, Ning Y,Ren K#, Cao J#. Isovitexin Inhibits Stemness and Induces Apoptosis in Hepatocellular Carcinoma SK-Hep-1 Spheroids by Upregulating miR-34a Expression.Anticancer Agents Med Chem.2020; 20(14):1654-1663. doi: 10.2174/1871520620666200424123139. PMID: 32329692.（通讯作者）
9. Q. Wen, C. Xu, J. Zhou, N.M. Liu, Y.H. Cui, M.F. Quan, J.G. Cao,Ren, K.#, 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells.BMC Cancer19 (2019) 224.（通讯作者）
10.Ren, K., Yuan, J., Yang, M., Gao, X., Ding, X., Zhou, J., Hu, X., Cao, J., Deng, X., Xiang, S. & Zhang, J. (2014) KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development,Plos One. 9, e112275.
11. Qu L, Liu FX, Cao XC, Xiao Q, Yang X,Ren K#. Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells.Exp Ther Med.2014 Nov;8(5):1494-1500. doi: 10.3892/etm.2014.1934. Epub 2014 Aug 26. PMID: 25289048; PMCID: PMC4186484.（通讯作者）
12. Jiang L, Cao XC, Cao JG, Liu F, Quan MF, Sheng XF,Ren K#. Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a. Oncol Lett. 2013 May;5(5):1605-1610. doi: 10.3892/ol.2013.1258. Epub 2013 Mar 14. PMID: 23761826; PMCID: PMC3678892.（通讯作者）
13.Ren K, Cao XZ, Liu ZH, Guo H, Quan MF, Liu F, Jiang L, Xiang HL, Deng XY, Cao JG#. 8-bromo-5-hydroxy-7-methoxychrysin targeting for inhibition of the properties of liver cancer stem cells by modulation of Twist signaling.Int J Oncol. 2013 Nov;43(5):1719-29. doi: 10.3892/ijo.2013.2071. Epub 2013 Aug 21. PMID: 23970349.
14.Ren K, Xian S, He F, Zhang W, Ding X, Wu Y, Yang L, Zhou J, Gao X, Zhang J#. CK2 phosphorylates AP-2α and increases its transcriptional activity.BMB Rep.2011 Jul;44(7):490-5. doi: 10.5483/BMBRep.2011.44.7.490. PMID: 21777522.
15. Zhou, J.,Ren, K., Liu, X., Xiong, X., Hu, X. & Zhang, J#. (2005) A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta,Biochimica et Biophysica Acta. 1729, 200-3.
